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Article

Gene expression profiles of single human mature oocytes in relation to age

10 Feb 2010

Abstract excerpt

BACKGROUND: The development competence of human oocytes declines with increasing age. The objective of this study was to investigate the effect of age on gene expression profile in mature human oocytes. METHODS: mRNA was isolated for whole genome gene expression microarray analysis from metaphase II (MII) oocytes donated by IVF or ICSI patients [10 women aged <36 years (younger) and five women aged 37-39 years...

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PMID: 20147335
DOI: 10.1093/humrep/deq014

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