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Article

Cryo-EM structure of the gasdermin A3 membrane pore.

Nature - 1 May 2018

Ruan Jianbin, Xia Shiyu, Liu Xing, Lieberman Judy, Wu Hao

Abstract excerpt

Gasdermins mediate inflammatory cell death after cleavage by caspases or other, unknown enzymes. The cleaved N-terminal fragments bind to acidic membrane lipids to form pores, but the mechanism of pore formation remains unresolved. Here we present the cryo-electron microscopy structures of the 27-fold and 28-fold single-ring pores formed by the N-terminal fragment of mouse GSDMA3 (GSDMA3-NT) at 3.8 and 4.2 Å...

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Identifiers

PMID: 29695864
DOI: 10.1038/s41586-018-0058-6
PMCID: PMC6007975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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