Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

alpha-Synuclein affects the MAPK pathway and accelerates cell death.

The Journal of biological chemistry - 30 Nov 2001

Iwata A, Maruyama M, Kanazawa I, Nukina N

Abstract excerpt

Insoluble alpha-synuclein accumulates in Parkinson's disease, diffuse Lewy body disease, and multiple system atrophy. However, the relationship between its accumulation and pathogenesis is still unclear. Recently, we reported that overexpression of alpha-synuclein affects Elk-1 phosphorylation in cultured cells, which is mainly performed by mitogen-activated protein kinases (MAPKs). We further examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Butadienes
Share to Coloring Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Nitriles

Share to Synucleins

Share to Tetrazolium Salts

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 11560921
DOI: 10.1074/jbc.M103736200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

alpha-Synuclein affects the MAPK pathway and accelerates cell death.PMID 11560921Read ↗

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.Semantic proximity Read ↗

MAPKs: new targets for neurodegenerationSemantic proximity Read ↗

DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau.Semantic proximity Read ↗

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.Semantic proximity Read ↗

MAPKAPK2, a potential dynamic network biomarker of α-synuclein prior to its aggregation in PD patientsSemantic proximity Read ↗

Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activationSemantic proximity Read ↗

E46K α-Synuclein Mutation Inhibits Cdc42EP2 Expression to Differentially Attenuate Neurite Outgrowth in SK-N-SH CellsSemantic proximity Read ↗

Unraveling the AKT/ERK cascade and its role in Parkinson diseaseSemantic proximity Read ↗

MAPKAPK2, a dynamic network biomarker of α-synuclein before its aggregation, was significantly highly expressed in both the brain and peripheral blood of PD patientsSemantic proximity Read ↗

Quantitative Phosphoproteomic Analysis in Alpha-Synuclein Transgenic Mice Reveals the Involvement of Aberrant p25/Cdk5 Signaling in Early-stage Parkinson’s DiseaseSemantic proximity Read ↗

PKB/AKT attenuates Lewy Body-like pathology in primary neurons via Cathepsins B and DSemantic proximity Read ↗

Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.