Article
Increased Levels of the Parkinson's Disease-Associated Gene ITPKB Correlate with Higher Expression Levels of α-Synuclein, Independent of Mutation Status.
International journal of molecular sciences - 19 Jan 2023
Di Leva Francesca, Filosi Michele, Oyston Lisa, Silvestri Erica, Picard Anne, Lavdas Alexandros A, Lobbestael Evy, Baekelandt Veerle, Neely G Gregory, Pramstaller Peter P, Hicks Andrew A, Corti Corrado
Abstract excerpt
Autosomal dominant mutations in the gene encoding α-synuclein (SNCA) were the first to be linked with hereditary Parkinson's disease (PD). Duplication and triplication of SNCA has been observed in PD patients, together with mutations at the N-terminal of the protein, among which A30P and A53T influence the formation of fibrils. By overexpressing human α-synuclein in the neuronal system of Drosophila, we...
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