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Article

Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.

Human molecular genetics - 15 Apr 2011

Dumitriu Alexandra, Pacheco Chris D, Wilk Jemma B, Strathearn Katherine E, Latourelle Jeanne C, Goldwurm Stefano, Pezzoli Gianni, Rochet Jean-Christophe, Lindquist Susan, Myers Richard H

Abstract excerpt

Although family history is a well-established risk factor for Parkinson's disease (PD), fewer than 5% of PD cases can be attributed to known genetic mutations. The etiology for the remainder of PD cases is unclear; however, neuronal accumulation of the protein α-synuclein is common to nearly all patients, implicating pathways that influence α-synuclein in PD pathogenesis. We report a genome-wide significant...

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PMID: 21258085
DOI: 10.1093/hmg/ddr026
PMCID: PMC3063983

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GAK

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