Article

Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.

2024-08-22

Abstract excerpt

<title>Abstract</title> <p>Potassium channels encoded by human Ether-à-go-go-Related Gene (hERG) are inhibited by diverse cardiac and non-cardiac drugs. Disopyramide is a chiral Class Ia antiarrhythmic that inhibits hERG at clinical concentrations. This study evaluated effects of disopyramide enantiomers on hERG current (IhERG) from hERG expressing HEK 293 cells at 37oC. S(+) and R(-) disopyramide inhibited wild-...

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Literature Corpus work: 0e52444f-9026-5031-a50c-db01767babcf
DOI: 10.21203/rs.3.rs-4770098/v1

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