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Article

Physicochemical features of the HERG channel drug binding site.

The Journal of biological chemistry - 12 Mar 2004

Fernandez David, Ghanta Azad, Kauffman Gregory W, Sanguinetti Michael C

Abstract excerpt

Blockade of hERG K(+) channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and sudden death. It has become common practice in the past few years to screen compounds for hERG channel activity early during the drug discovery process. Understanding the molecular basis of drug binding to hERG is crucial for the rational design of medications devoid of this activity. We...

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Identifiers

PMID: 14699101
DOI: 10.1074/jbc.M310683200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Physicochemical features of the HERG channel drug binding site.PMID 14699101Read ↗

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