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Article

Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular pharmacology - 1 Oct 2011

Garg Vivek, Stary-Weinzinger Anna, Sachse Frank, Sanguinetti Michael C

Abstract excerpt

Human ether-à-go-go-related gene 1 (hERG1) channels mediate repolarization of cardiac action potentials. Inherited long QT syndrome (LQTS) caused by loss-of-function mutations, or unintended blockade of hERG1 channels by many drugs, can lead to severe arrhythmia and sudden death. Drugs that activate hERG1 are a novel pharmacological approach to treat LQTS. 3-Nitro-n-(4-phenoxyphenyl) benzamide [ICA-105574 (ICA)]...

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Identifiers

PMID: 21743002
DOI: 10.1124/mol.111.073809
PMCID: PMC3187531

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