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Article

The evolutionarily conserved residue A653 plays a key role in HERG channel closing.

The Journal of physiology - 1 Jun 2009

Stepanovic Svetlana Z, Potet Franck, Petersen Christina I, Smith Jarrod A, Meiler Jens, Balser Jeffrey R, Kupershmidt Sabina

Abstract excerpt

Human ether-a-go-go-related gene (HERG) encodes the rapid, outwardly rectifying K(+) current I(Kr) that is critical for repolarization of the cardiac action potential. Congenital HERG mutations or unintended pharmaceutical block of I(Kr) can lead to life-threatening arrhythmias. Here, we assess the functional role of the alanine at position 653 (HERG-A653) that is highly conserved among evolutionarily divergent...

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Identifiers

PMID: 19406877
DOI: 10.1113/jphysiol.2008.166694
PMCID: PMC2714020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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