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Article

Intermittent hypoxia selects for genotypes and phenotypes that increase survival, invasion, and therapy resistance.

PloS one - 1 Jan 2015

Verduzco Daniel, Lloyd Mark, Xu Liping, Ibrahim-Hashim Arig, Balagurunathan Yoganand, Gatenby Robert A, Gillies Robert J

Abstract excerpt

Hypoxia in tumors correlates with greater risk of metastases, increased invasiveness, and resistance to systemic and radiation therapy. The evolutionary dynamics that links specific adaptations to hypoxia with these observed tumor properties have not been well investigated. While some tumor populations may experience fixed hypoxia, cyclical and stochastic transitions from normoxia to hypoxia are commonly observed...

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Identifiers

PMID: 25811878
DOI: 10.1371/journal.pone.0120958
PMCID: PMC4374837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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