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Article

A Mathematical Study of the Influence of Hypoxia and Acidity on the Evolutionary Dynamics of Cancer.

Bulletin of mathematical biology - 15 Jun 2021

Fiandaca Giada, Delitala Marcello, Lorenzi Tommaso

Abstract excerpt

Hypoxia and acidity act as environmental stressors promoting selection for cancer cells with a more aggressive phenotype. As a result, a deeper theoretical understanding of the spatio-temporal processes that drive the adaptation of tumour cells to hypoxic and acidic microenvironments may open up new avenues of research in oncology and cancer treatment. We present a mathematical model to study the influence of...

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Identifiers

PMID: 34129102
DOI: 10.1007/s11538-021-00914-3
PMCID: PMC8205926

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