Article
Modeling treatment-dependent glioma growth including a dormant tumor cell subpopulation.
BMC cancer - 3 Apr 2018
Böttcher Marvin A, Held-Feindt Janka, Synowitz Michael, Lucius Ralph, Traulsen Arne, Hattermann Kirsten
Abstract excerpt
BACKGROUND: Tumors comprise a variety of specialized cell phenotypes adapted to different ecological niches that massively influence the tumor growth and its response to treatment. METHODS: In the background of glioblastoma multiforme, a highly malignant brain tumor, we consider a rapid proliferating phenotype that appears susceptible to treatment, and a dormant phenotype which lacks this pronounced proliferative...
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