Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasis

1 Jul 2024

Abstract excerpt

Oxygen played a pivotal role in the evolution of multicellularity during the Cambrian Explosion. Not surprisingly, responses to fluctuating oxygen concentrations are integral to the evolution of cancer-a disease characterized by the breakdown of multicellularity. Poorly organized tumor vasculature results in chaotic patterns of blood flow characterized by large spatial and temporal variations in intra-tumoral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38969311
DOI: 10.1016/j.semcancer.2024.06.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasisPMID 38969311Read ↗

HIF-1 — A BIG CHAPTER IN THE CANCER TALESemantic proximity Read ↗

Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF GenesSemantic proximity Read ↗

Hypoxia‐inducible factor 1 and cancer pathogenesisSemantic proximity Read ↗

Targeting Hypoxia-Driven Metabolic Reprogramming to Constrain Tumor Progression and MetastasisSemantic proximity Read ↗

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunitySemantic proximity Read ↗

Hypoxia Signaling in Cancer: From Basics to Clinical PracticeSemantic proximity Read ↗

Understanding the tumor metabolic phenotype in the genomic era.Semantic proximity Read ↗

Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor ProgressionSemantic proximity Read ↗

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations.Semantic proximity Read ↗

Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be OvercomeSemantic proximity Read ↗

Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistanceSemantic proximity Read ↗

Expression of hypoxia-inducible factor 1: mechanisms and consequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.