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An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin

2 Sept 2020

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor, characterized by a high degree of intertumoral heterogeneity. However, a common feature of the GBM microenvironment is hypoxia, which can promote radio- and chemotherapy resistance, immunosuppression, angiogenesis, and stemness. We experimentally defined common GBM adaptations to physiologically relevant oxygen gradients, and we...

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PMID: 32887267
DOI: 10.3390/biology9090264

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