Article

Remyelination protects neurons from DLK-mediated neurodegeneration

2023-10-02

Abstract excerpt

Chronic demyelination and oligodendrocyte loss deprive neurons of crucial support. It is the degeneration of neurons and their connections that drives progressive disability in demyelinating disease. However, whether chronic demyelination triggers neurodegeneration and how it may do so remain unclear. We characterize two genetic mouse models of inducible demyelination, one distinguished by effective remyelination...

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Literature Corpus work: ecea2b9f-0dfc-5f68-9d37-3070b2cf60d0
DOI: 10.1101/2023.09.30.560267

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