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Fundamentally Different Roles of Neuronal TNF Receptors in CNS Pathology: TNFR1 and IKKβ Promote Microglial Responses and Tissue Injury in Demyelination, TNFR2 Protects in Excitotoxicity in Mice

2021-01-05

Abstract excerpt

<title>Abstract</title> <p>BACKGROUNDDuring inflammatory demyelination TNF receptor 1 (TNFR1) mediates detrimental proinflammatory effects of soluble TNF, whereas TNFR2 mediates beneficial effects of transmembrane TNF through oligodendrocytes, microglia, and possibly other cell types. This model supports use of selective inhibitors of soluble TNF/TNFR1 as antinflammatory drugs for CNS disease. A potential obstacl...

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Literature Corpus work
12d443d2-12cc-5d9e-884f-357465cc94f7
DOI
10.21203/rs.3.rs-136877/v1
Open publication

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Fundamentally Different Roles of Neuronal TNF Receptors in CNS Pathology: TNFR1 and IKKβ&nbsp;Promote Microglial Responses and Tissue Injury in Demyelination, TNFR2 Protects in Excitotoxicity in MiceDOI 10.21203/rs.3.rs-136877/v1
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