Article
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis.
The Journal of experimental medicine - 4 May 2020
Cunha Maria Inês, Su Minhui, Cantuti-Castelvetri Ludovico, Müller Stephan A, Schifferer Martina, Djannatian Minou, Alexopoulos Ioannis, van der Meer Franziska, Winkler Anne, van Ham Tjakko J, Schmid Bettina, Lichtenthaler Stefan F, Stadelmann Christine, Simons Mikael
Abstract excerpt
Remyelination requires innate immune system function, but how exactly microglia and macrophages clear myelin debris after injury and tailor a specific regenerative response is unclear. Here, we asked whether pro-inflammatory microglial/macrophage activation is required for this process. We established a novel toxin-based spinal cord model of de- and remyelination in zebrafish and showed that pro-inflammatory...
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