Evolution of simple sequence repeats as mutable sites.

Abstract excerpt

Because natural selection is commonly presumed to minimize mutation rates, the discovery of mutationally unstable simple sequence repeats (SSRs) in many functional genomic locations came as a surprise to many biologists. Whether such SSRs persist in spite of or because of their intrinsic mutability-whether they constitute a genetic burden or an evolutionary boon--remains uncertain. Two contrasting evolutionary...

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