Article

Unexpected Properties of Short Genomic Tandem Repeats

2017-07-18

Abstract excerpt

Length polymorphisms in genomic short tandem repeats have been implicated in a variety of diseases, most notably human neurodegenerative disorders. Expansions of tandem repeats are also associated with genomic instability in cancer. Our previous study of length-3 tandem repeats uncovered a surprising pattern in the length distribution of certain such repeats in the non-coding regions of the human reference genome:...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 371068e8-286a-5f44-8971-3196e38b7e79
DOI: 10.1101/165308

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unexpected Properties of Short Genomic Tandem RepeatsDOI 10.1101/165308Read

Triplet repeat length bias and variation in the human transcriptome.Semantic proximity Read

Tandem repeat polymorphisms: Mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility.Semantic proximity Read

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general populationSemantic proximity Read

Inherent instability of simple DNA repeats shapes an evolutionarily stable distribution of repeat lengthsSemantic proximity Read

Genome-wide Survey of Tandem Repeats by Nanopore Sequencing Shows that Disease-associated Repeats are More Polymorphic in the General PopulationSemantic proximity Read

A comprehensive tandem repeat catalog of the human genomeSemantic proximity Read

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population.Semantic proximity Read

Tandem repeats mediating genetic plasticity in health and disease.Semantic proximity Read

Analysis of the largest tandemly repeated DNA families in the human genome.Semantic proximity Read

Comparative analyses of human single- and multilocus tandem repeats.Semantic proximity Read

TRPing up the genome: Tandem repeat polymorphisms as dynamic sources of genetic variability in health and disease.Semantic proximity Read

Short Tandem Repeats of Human Genome Are Intrinsically Unstable in Cultured Cells <i>in vivo</i>Semantic proximity Read