Article
Nuclear Lamins: Thin Filaments with Major Functions.
Trends in cell biology - 1 Jan 2018
de Leeuw Rebecca, Gruenbaum Yosef, Medalia Ohad
Abstract excerpt
The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear lamins, although a small fraction of lamins also localizes throughout the nucleoplasm. Lamins are classified as type V intermediate filament (IF) proteins. Mutations in lamin genes cause at least 15 distinct human diseases, collectively termed laminopathies, including muscle, metabolic, and neuronal diseases, and can cause...
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