Article

A lamin A/C variant causing striated muscle disease provides insights into filament organization

2020-10-20

Abstract excerpt

The LMNA gene encodes the A-type lamins that polymerize into ~3.5 nm thick filaments, and together with B-type lamins and lamin binding proteins form the nuclear lamina. Mutations in LMNA are associated with a wide variety of pathologies. In this study, we analyzed the nuclear lamina of embryonic fibroblasts from Lmna H222P/H222P mice, which develop cardiomyopathy and muscular dystrophy. Although the organizati...

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Literature Corpus work: 4bc0b41c-c97a-5af2-836e-328046ba5c24
DOI: 10.1101/2020.10.20.347088

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