Article
Nuclear lamina remodelling and its implications for human disease.
Cell and tissue research - 1 Jun 2015
Chojnowski Alexandre, Ong Peh Fern, Dreesen Oliver
Abstract excerpt
The intermediate filament A- and B-type lamins are key architectural components of the nuclear lamina, a proteinaceous meshwork that lies underneath the inner nuclear membrane. In the past decade, many different monogenic human diseases have been linked to mutations in various components of the nuclear lamina. Mutations in LMNA (encoding lamin A and C) cause a variety of human diseases, collectively called...
Topics
- Animals
- Cellular Senescence
- Disease
- Genetic Predisposition to Disease
- Humans
- Lamins
- Mutation
- Nuclear Lamina