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Article

A lamin A/C variant causing striated muscle disease provides insights into filament organization.

Journal of cell science - 22 Mar 2021

Kronenberg-Tenga Rafael, Tatli Meltem, Eibauer Matthias, Wu Wei, Shin Ji-Yeon, Bonne Gisèle, Worman Howard J, Medalia Ohad

Abstract excerpt

The LMNA gene encodes the A-type lamins, which polymerize into ∼3.5-nm-thick filaments and, together with B-type lamins and associated proteins, form the nuclear lamina. Mutations in LMNA cause a wide variety of pathologies. In this study, we analyzed the nuclear lamina of embryonic fibroblasts from LmnaH222P/H222P mice, which develop cardiomyopathy and muscular dystrophy. Although the organization of the lamina...

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Identifiers

PMID: 33536248
DOI: 10.1242/jcs.256156
PMCID: PMC8015223

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