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Human organoids reveal PTEN-driven mesendoderm specification via retinoic acid signaling suppression

2025-10-17

Abstract excerpt

During early embryogenesis, epiblast cells ingress through the primitive streak (PS) and commit to a mesendoderm (MES) fate, giving rise to both mesodermal and endodermal lineages. Despite advancements in human organoid technology for modeling pre-implantation blastocyst stage, robust systems that accurately recapitulate MES specification and PS formation during the post-implantation stage remain limited. Here, we...

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Literature Corpus work
ece06fdd-6e45-50d3-ac48-ff7bda26d500
DOI
10.1101/2025.10.17.682808
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Human organoids reveal PTEN-driven mesendoderm specification via retinoic acid signaling suppressionDOI 10.1101/2025.10.17.682808
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