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Retinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification

1 Jan 2020

Abstract excerpt

Retinoic acid (RA) signaling is essential for multiple developmental processes, including appropriate pancreas formation from the foregut endoderm. RA is also required to generate pancreatic progenitors from human pluripotent stem cells. However, the role of RA signaling during endocrine specification has not been fully explored. In this study, we demonstrate that the disruption of RA signaling within the...

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PMID: 32467243
DOI: 10.1242/dev.189977

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