Article
Liver-specific T regulatory type-1 cells program local neutrophils to suppress hepatic autoimmunity via CRAMP.
Cell reports - 30 Mar 2021
Umeshappa Channakeshava Sokke, Solé Patricia, Surewaard Bas G J, Yamanouchi Jun, Mohapatra Saswat, Uddin Muhammad Myn, Clarke Robert, Ortega Mireia, Singha Santiswarup, Mondal Debajyoti, Yang Yang, Vignali Dario A A, Serra Pau, Kubes Paul, Santamaria Pere
Abstract excerpt
Neutrophils with immunoregulatory properties, also referred to as type-2 neutrophils (N2), myeloid-derived suppressor cells (MDSCs), or tumor-associated neutrophils (TANs), comprise a heterogeneous subset of cells that arise from unknown precursors in response to poorly understood cues. Here, we find that, in several models of liver autoimmunity, pharmacologically induced, autoantigen-specific T regulatory type-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.