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Article

A model of lysosomal pH regulation.

The Journal of general physiology - 1 Jun 2013

Ishida Yoichi, Nayak Smita, Mindell Joseph A, Grabe Michael

Abstract excerpt

Lysosomes must maintain an acidic luminal pH to activate hydrolytic enzymes and degrade internalized macromolecules. Acidification requires the vacuolar-type H(+)-ATPase to pump protons into the lumen and a counterion flux to neutralize the membrane potential created by proton accumulation. Early experiments suggested that the counterion was chloride, and more recently a pathway consistent with the ClC-7...

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Identifiers

PMID: 23712550
DOI: 10.1085/jgp.201210930
PMCID: PMC3664703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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