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Article

PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation.

Molecular biology of the cell - 15 Jul 2018

Wilson Zachary N, Scott Amber L, Dowell Robin D, Odorizzi Greg

Abstract excerpt

Lysosomes are dynamic organelles with critical roles in cellular physiology. The lysosomal signaling lipid phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a key regulator that has been implicated to control lysosome ion homeostasis, but the scope of ion transporters targeted by PI(3,5)P2 and the purpose of this regulation is not well understood. Through an unbiased screen in Saccharomyces cerevisiae, we...

Topics

Acids
Cations
Ion Transport
Mutation
Osmoregulation
Phosphatidylinositol Phosphates
Potassium
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Suppression, Genetic
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vacuolar Proton-Translocating ATPases

Vacuoles

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Identifiers

PMID: 29791245
DOI: 10.1091/mbc.E18-01-0015
PMCID: PMC6080712

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