Article

Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics

2026-08-28

Abstract excerpt

Reference proteomes incompletely represent proteins translated in cancer, leaving tumor-specific proteoforms outside the search space of conventional mass spectrometry (MS). Such "dark proteome" products may arise from genomic variation, aberrant transcription or splicing, and non-canonical translation, including microproteins encoded by small open reading frames (ORFs). To define this landscape in acute myeloid l...

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Literature Corpus work: 5222f026-d965-53f5-84aa-ca32e98609fc
DOI: 10.64898/2026.08.27.747547

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