Article

DPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins

2023-01-08

Abstract excerpt

<h4>Summary</h4> A comprehensive pan-human spectral library is critical for biomarker discovery using mass spectrometry (MS)-based proteomics. DPHL v1, a previous pan-human library built from 1096 data-dependent acquisition (DDA) MS data of 16 human tissue types, allows quantifying 10,943 proteins. However, a major limitation of DPHL v1 is the lack of semi-tryptic peptides and protein isoforms, which are abundant...

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Literature Corpus work: f0ed0da8-4e04-5c83-bd43-a2fdb3fd1ce3
DOI: 10.1101/2023.01.07.523067

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