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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD mice

2023-12-20

Abstract excerpt

<title>Abstract</title> <p>The complex pathology of Alzheimer disease (AD) has led to failure of multiple drugs in clinical trials. We hypothesized that targeting multiple aspects AD pathology may yield better results. Therefore, we identified isobavachalcone (IBC) as a natural compound with dual activity against AD pathology. IBC caused AMPK phosphorylation through CAMKK2 to induce autophagy and inhibit NLRP3 in...

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Literature Corpus work
ecba8316-693d-5fe5-b4ff-cb8324346666
DOI
10.21203/rs.3.rs-3762830/v1
Open publication

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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD miceDOI 10.21203/rs.3.rs-3762830/v1
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