Back to search

Article

Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's Disease

2021-03-16

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a devastating brain disorder characterized by neurofibrillary tangles and amyloid plaques. Inhibiting Tau protein and amyloid-beta (Aβ) production or removing these molecules are considered potential therapeutic strategies for AD. Genipin is an aglycone and is isolated from the extract of <italic>Gardenia jasminoides</italic> Ellis fruit. In this study, the e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0c055de5-4ba3-5ec9-bbca-a469a37fd3a0
DOI
10.21203/rs.3.rs-309753/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genipin Attenuates Tau Phosphorylation and Aβ Levels in Cellular Models of Alzheimer's DiseaseDOI 10.21203/rs.3.rs-309753/v1
Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease.Semantic proximity
Gomisin N rescues cognitive impairment of Alzheimer's disease by targeting GSK3β and activating Nrf2 signaling pathwaySemantic proximity
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.Semantic proximity
Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD miceSemantic proximity
Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological propertiesSemantic proximity
A Review on the Research Progress of Mechanism of <em>Panax ginseng C. A. meyer </em>in the Treatment of Alzheimer’s DiseaseSemantic proximity
Network Pharmacology-guided Identification and Molecular Validation of Multi-Target Phytoconstituents from Gmelina arborea against Alzheimer’s DiseaseSemantic proximity
Ginkgo biloba Extract EGb 761 and Its Specific Components Elicit Protective Protein Clearance Through the Autophagy-Lysosomal Pathway in Tau-Transgenic Mice and Cultured Neurons.Semantic proximity
Network Pharmacology-guided Identification and Molecular Validation of Multi-Target Phytoconstituents from Gmelina arborea against Alzheimer’s DiseaseSemantic proximity
Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular dockingSemantic proximity
Xanthoangelol Mitigates Neuroinflammation and Hypoxia via MAPK and HIF-1 Signaling Modulation: Network Pharmacology and In-Vivo Approach in a Haloperidol-Induced Model of Parkinson’s DiseaseSemantic proximity
Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.