Article

Fluvoxamine maleate ameliorates Alzheimer disease pathology by mitigating amyloid-beta load and neuroinflammation in 5XFAD mice

2023-12-18

Abstract excerpt

<h4>Background</h4> Alzheimer pathology (AD) is accompanied by the deposition of amyloid beta (Aβ) and chronic neuroinflammation, where NLRP3 inflammasome is particularly involved. In this study, we found that the OCD drug fluvoxamine maleate (FXN) can potently ameliorate AD pathology in 5XFAD mice by autophagy-mediated clearance of Aβ and inhibition of NLRP3 inflammasome. <h4>Methods</h4> We used mice primary a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea49e043-959b-5020-b23b-2f1f968576c2
DOI: 10.1101/2023.12.17.572086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fluvoxamine maleate ameliorates Alzheimer disease pathology by mitigating amyloid-beta load and neuroinflammation in 5XFAD miceDOI 10.1101/2023.12.17.572086Read

Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in 5XFAD miceSemantic proximity Read

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregationSemantic proximity Read

mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-DependentSemantic proximity Read

Neurotrophic Factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer’s Disease miceSemantic proximity Read

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.Semantic proximity Read

Positron emission tomography imaging of the P2X7 receptor with a novel tracer, [18F]GSK1482160, in a transgenic mouse model of Alzheimer's disease and healthy non‐human primatesSemantic proximity Read

Melatonin Ameliorates the Progression of Alzheimer’s Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome ActivitySemantic proximity Read

Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.Semantic proximity Read

Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced AutophagySemantic proximity Read

Effect of Fluvoxamine on Amyloid-β Peptide Generation and Memory.Semantic proximity Read

The autophagy activator Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse modelSemantic proximity Read

Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathwaySemantic proximity Read