Article

Clemastine Attenuates AD-like Pathology in an AD Model Mouse via Enhancing mTOR-Mediated Autophagy

2020-06-29

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Alzheimer’s disease (AD) is a neurodegenerative disorder with limited available drugs for treatment. Enhancing autophagy attenuates AD pathology in various AD model mice. Thus, development of potential drugs enhancing autophagy may bring beneficial effects in AD therapy. <bold>Methods: </bold>In the present study, we showed clemastine, a first-generation histami...

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Literature Corpus work: 3df82f26-1f42-56b3-98bd-2723a1a566bd
DOI: 10.21203/rs.3.rs-36989/v1

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