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Article

IKAROS and AIOLOS activate AP-1 transcriptional complexes and are essential for natural killer cell development

2022-11-02

Abstract excerpt

<title>Abstract</title> <p>Ikaros family transcription factors regulate lymphocyte biology and are targets of the immunomodulatory imide drugs (IMiDs) for hematological maligancies. Ikaros (Ikzf1/IKZF1) is the most broadly expressed family member in lymphocytes, yet its role in innate lymphopoiesis was unknown. Here we used conditional gene inactivation to reveal that Ikaros is required for normal NK cell develop...

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Literature Corpus work
ecab0f12-a263-5517-aace-311bf1a9503a
DOI
10.21203/rs.3.rs-2196744/v1
Open publication

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IKAROS and AIOLOS activate AP-1 transcriptional complexes and are essential for natural killer cell developmentDOI 10.21203/rs.3.rs-2196744/v1
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