Article

Conserved helical motifs in the Ikaros IDR mediate NuRD interaction and transcriptional repression

2024-02-29

Abstract excerpt

The transcription factor IKZF1/Ikaros is essential for B cell development, and recurrently mutated in human B-ALL. Ikaros has been ascribed both activating and repressive functions via interactions with coactivator and corepressor complexes, but the relative abundance of Ikaros-associated coregulatory complexes and their contribution to Ikaros-mediated gene regulation are not well understood. To address this issue...

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Literature Corpus work: 0eb4cd5e-2520-5696-8fa6-f63be5038cc8
DOI: 10.1101/2024.02.29.582782

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