Article

Single cell transcriptomics reveals the effect of PD-L1/TGF-β blockade on the tumor microenvironment

2020-11-14

Abstract excerpt

<h4>Background</h4> The anti-tumor activity of anti-PD-1/PD-L1 therapies correlates with T cell infiltration in tumors. Thus, a major goal in oncology is to find strategies that enhance T cell infiltration and efficacy of anti-PD-1/PD-L1 therapy. TGF-β has been shown to contribute to T cell exclusion and anti-TGF-β improves anti-PD-L1 efficacy in vivo . However, TGF-β inhibition has frequently been shown to indu...

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Literature Corpus work: 3c4664d3-9832-5bf7-a3fa-645fba167ccd
DOI: 10.1101/2020.11.13.382358

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