Article

Imatinib mesylate reduces c-Myc translocation in double-hit lymphoma cells by suppressing inducible cytidine deaminase

2024-05-31

Abstract excerpt

<title>Abstract</title> <p>Double-hit lymphoma (DHL) with c-Myc gene translocation is highly aggressive and has a poor prognosis. In DHL cells, activation-induced cytidine deaminase (AID) promotes antibody class switch recombination (CSR), ultimately leading to c-Myc gene translocation caused by Myc/IgH DNA double-strand breaks. In this study, imatinib mesylate downregulated the AID and c-Myc proteins in patients...

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Literature Corpus work: ec955969-a235-5678-8735-baf5c4c7bb3a
DOI: 10.21203/rs.3.rs-4368255/v1

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