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Article

MYC‐associated and double‐hit lymphomas: A review of pathobiology, prognosis, and therapeutic approaches

24 Jul 2014

Abstract excerpt

Aberrant expression of the v-myc avian myelocytomatosis viral oncogene homolog (MYC) proto-oncogene has known transformative potential in healthy human cells. Chromosomal MYC rearrangements and consequent MYC overexpression is the defining lesion in Burkitt lymphoma (BL), conferring a highly proliferative state. However, abnormalities of MYC are increasingly appreciated in non-BL histologies, including diffuse...

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PMID: 25060588
DOI: 10.1002/cncr.28899

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