Article
LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates.
Structure (London, England : 1993) - 2 Jan 2025
Lesire Saskia, Lata Rodrigo, Hoogvliets Yannick, Herrebosch Kune, Van De Velde Paulien, Speleers Anouk, Christ Frauke, Van Belle Siska, Debyser Zeger
Abstract excerpt
Methyl-CpG-binding protein 2 (MeCP2) is a ubiquitously expressed nuclear protein involved in transcriptional regulation and chromatin remodeling. MeCP2 exists in two isoforms, MeCP2 E1 and E2, which share the same functional domains. Loss-of-function mutations in the MeCP2 gene are the main cause of Rett syndrome (RTT). Previous studies identified a complex formation between MeCP2 and lens epithelium derived...
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