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Article

MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein?

Current opinion in genetics & development - 1 Apr 2007

Chadwick Lisa Helbling, Wade Paul A

Abstract excerpt

Rett syndrome is a progressive neurological disorder caused by mutations in the methyl-DNA binding protein MeCP2. The longstanding model depicting MeCP2 as a transcriptional repressor predicts that the Rett syndrome phenotype probably results from misregulation of MeCP2 target genes. Somewhat unexpectedly, the identification of such targets has proven challenging. The recent identification of two MeCP2 targets,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17317146
DOI: 10.1016/j.gde.2007.02.003

Genes

BDNF
DLX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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