A Proximity MAP of RAB GTPases

Abstract excerpt

<h4>ABSTRACT</h4> RAB GTPases are the most abundant family of small GTPases and regulate multiple aspects of membrane trafficking events, from cargo sorting to vesicle budding, transport, docking, and fusion. To regulate these processes, RABs are tightly regulated by guanine exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RABs recruit effector proteins that regulate trafficking. Identifyi...

Topics

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• Amino Acid Sequence
• Evolution, Molecular
• Intracellular Membranes
• Models, Biological
• Molecular Sequence Data
• Phylogeny
• Protein Conformation
• rab GTP-Binding Proteins

Identifiers and source

Literature Corpus work

52d77a81-390d-5753-8f0a-144f63723673

DOI

10.1101/2024.11.05.621850