Article
Analysis of K-Ras Interactions by Biotin Ligase Tagging.
Cancer genomics & proteomics - 1 Jan 2000
Ritchie Christopher, Mack Andrew, Harper Logan, Alfadhli Ayna, Stork Philip J S, Nan Xiaolin, Barklis Eric
Abstract excerpt
BACKGROUND: Mutations of the human K-Ras 4B (K-Ras) G protein are associated with a significant proportion of all human cancers. Despite this fact, a comprehensive analysis of K-Ras interactions is lacking. Our investigations focus on characterization of the K-Ras interaction network. MATERIALS AND METHODS: We employed a biotin ligase-tagging approach, in which tagged K-Ras proteins biotinylate neighbor proteins...
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