Article

Comparative proximity biotinylation implicates RAB18 in sterol mobilization and biosynthesis

2019-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Loss of functional RAB18 causes the autosomal recessive condition Warburg Micro syndrome. To better understand this disease, we used proximity biotinylation to generate an inventory of potential RAB18 effectors. A restricted set of 28 RAB18-interactions were dependent on the binary RAB3GAP1-RAB3GAP2 RAB18-guanine nucleotide exchange factor (GEF) complex. 12 of these 28 interactions are supported...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c79ad404-c06d-550a-846a-340ddc3841b7
DOI: 10.1101/871517

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative proximity biotinylation implicates RAB18 in sterol mobilization and biosynthesisDOI 10.1101/871517Read

Global Proximity Interactome of the Human Macroautophagy PathwaySemantic proximity Read

Rab18 and a Rab18 GEF complex are required for normal ER structure.Semantic proximity Read

Loss-of-function mutations in RAB18 cause Warburg micro syndrome.Semantic proximity Read

Proximity-dependent proteomics reveals extensive interactions of Protocadherin-19 with regulators of Rho GTPases and the microtubule cytoskeletonSemantic proximity Read

Analysis of K-Ras Interactions by Biotin Ligase Tagging.Semantic proximity Read

In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylationSemantic proximity Read

The p97-UBXD8 complex modulates ER-Mitochondria contact sites by modulating membrane lipid saturation and compositionSemantic proximity Read

A Proximity MAP of RAB GTPasesSemantic proximity Read

Presenilin-2 interacts with Lamtor1 at late endosome/lysosome-endoplasmic reticulum contact sites to guard endolysosomal homeostasisSemantic proximity Read

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesisSemantic proximity Read

Loss-of-Function Mutations in RAB18 Cause Warburg Micro SyndromeSemantic proximity Read

Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome.Semantic proximity Read