Article

Disruption of a Hedgehog-Foxf1-Rspo2 Signaling Axis Leads to Tracheomalacia and a Loss of Sox9+ Tracheal Chondrocytes

2020-07-11

Abstract excerpt

<h4>ABSTRACT</h4> Congenital tracheomalacia, resulting from incomplete tracheal cartilage development, is a relatively common birth defect that severely impairs breathing in neonates. Mutations in the Hedgehog (HH) pathway and downstream Gli transcription factors are associated with tracheomalacia in patients and mouse models; however, the underlying molecular mechanisms are unclear. Using multiple HH/Gli mouse...

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Literature Corpus work: ec5fd3f5-c3e4-5250-93c0-6ca843cdf96e
DOI: 10.1101/2020.07.11.198556

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