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Article

Osr1 functions downstream of Hedgehog pathway to regulate foregut development.

Developmental biology - 1 Jul 2017

Han Lu, Xu Jingyue, Grigg Emily, Slack Megan, Chaturvedi Praneet, Jiang Rulang, Zorn Aaron M

Abstract excerpt

During early fetal development, paracrine Hedgehog (HH) ligands secreted from the foregut epithelium activate Gli transcription factors in the surrounding mesenchyme to coordinate formation of the respiratory system, digestive track and the cardiovascular network. Although disruptions to this process can lead to devastating congenital defects, the underlying mechanisms and downstream targets, are poorly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Zinc Finger Protein Gli2

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Source

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Identifiers

PMID: 28501478
DOI: 10.1016/j.ydbio.2017.05.005
PMCID: PMC5519324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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