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Hedgehog and Platelet-derived Growth Factor Signaling Intersect during Postnatal Lung Development

24 Jan 2023

Abstract excerpt

Abstract Normal lung development critically depends on HH (Hedgehog) and PDGF (platelet-derived growth factor) signaling, which coordinate mesenchymal differentiation and proliferation. PDGF signaling is required for postnatal alveolar septum formation by myofibroblasts. Recently, we demonstrated a requirement for HH in postnatal lung development involving alveolar myofibroblast differentiation. Given shared...

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PMID: 36693140
DOI: 10.1165/rcmb.2022-0269oc

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