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Glycoengineered recombinant alpha1-antitrypsin results in comparable <i>in vitro</i> and <i>in vivo</i> activities to human plasma-derived protein

2024-03-30

Abstract excerpt

Alpha-1-antitrypsin (A1AT) is a multifunctional, clinically important, high value therapeutic glycoprotein that can be used for the treatment of many diseases such as alpha-1-antitrypsin deficiency, diabetes, graft-versus-host-disease, cystic fibrosis and various viral infections. Currently, the only FDA-approved treatment for A1AT disorders is intravenous augmentation therapy with human plasma-derived A1AT. In ad...

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Literature Corpus work
ec56679d-3778-5e36-a1a1-14ca247ff9d0
DOI
10.1101/2024.03.27.587088
Open publication

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Glycoengineered recombinant alpha1-antitrypsin results in comparable <i>in vitro</i> and <i>in vivo</i> activities to human plasma-derived proteinDOI 10.1101/2024.03.27.587088
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