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Cell-based production of Fc-GlcNAc and Fc-alpha-2,6 sialyl glycan enriched antibody with improved effector functions through glycosylation pathway engineering

2023-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Glycosylation of antibody plays an important role in Fc-mediated killing of tumor cells and virus-infected cells through effector functions such as antibody-dependent cellular cytotoxicity (ADCC), antibody dependent cell-mediated phagocytosis (ADCP) and vaccinal effect. Previous studies showed that therapeutical humanized antibodies with α2-6 sialyl complex type (SCT) glycan attached to Fc-Asn29...

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Literature Corpus work
84bbd5cc-b982-5340-986d-c60d9b7f3d9d
DOI
10.1101/2023.12.18.572280
Open publication

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Cell-based production of Fc-GlcNAc and Fc-alpha-2,6 sialyl glycan enriched antibody with improved effector functions through glycosylation pathway engineeringDOI 10.1101/2023.12.18.572280
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