Article

<i>In Vivo</i> Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells

2023-01-03

Abstract excerpt

<h4>Summary</h4> Human induced pluripotent stem cells (iPSCs) have already been used in transplantation therapies. Currently, cells from healthy people are transplanted into patients with diseases. With the rapid evolution of genome editing technology, genetic modification could be applied to enhance the therapeutic effects of iPSCs, such as the introduction of secreted molecules to make the cells a drug delivery...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c85568a5-c703-57aa-a2b4-93a2aec2fe00
DOI: 10.1101/2023.01.03.522057

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In Vivo</i> Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem CellsDOI 10.1101/2023.01.03.522057Read

Gene therapy for Fabry disease: Progress, challenges, and outlooks on gene-editing.Semantic proximity Read

Generation of human induced pluripotent stem cell line MHHi029-A from a male Fabry disease patient carrying c.959A > T mutation.Semantic proximity Read

Human in vitro models for Fabry disease: new paths for unravelling disease mechanisms and therapies.Semantic proximity Read

Secreted Particle Information Transfer (SPIT) – A Cellular Platform for <i>In Vivo</i> Genetic EngineeringSemantic proximity Read

Induced Pluripotency and Gene Editing in Disease Modelling: Perspectives and ChallengesSemantic proximity Read

Modeling Adeno-Associated Viral Vector 6-mediated <i>In Vivo</i> Gene Delivery to Expanded Non-Mobilized Haemopoietic Stem Cells from Transfusion-dependent Thalassemia Patients in a Humanized MouseSemantic proximity Read

Secreted Particle Information Transfer (SPIT) – A Cellular Platform for In Vivo Genetic EngineeringSemantic proximity Read

Pluripotent stem cell-based immunotherapy: advances in translational research, cell differentiation, and gene modificationsSemantic proximity Read

Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage DisordersSemantic proximity Read

Twenty-Five Years of Gene Therapy for ADA-SCID: From <i>Bubble Babies</i> to an Approved DrugSemantic proximity Read

Retroviral gene therapy in Germany with a view on previous experience and future perspectivesSemantic proximity Read

Secreted cytokines provide local immune tolerance for human stem cell-derived isletsSemantic proximity Read